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Clinicopathologic studies on leptomeningeal glioneuronal heterotopia in congenital anomalies
S Hirano1, S Houdou, M Hasegawa
1Division of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, Tokyo, Japan.
Pediatric Neurology
|November 1, 1992
Abstract:
Leptomeningeal glioneuronal heterotopia was observed in 40 of 129 autopsied infants (31%). It was present in 49% of patients who had congenital anomalies in general and in 65% of patients who had central nervous system malformations. Most of the leptomeningeal glioneuronal heterotopias appeared in the base of the brain (62.5%), midbrain (40%), frontal lobe (37%), and pons (35%). Leptomeningeal glioneuronal heterotopia is closely related to migration disorders on the basis of frequent association with polymicrogyria or neuronal heterotopias.