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Updated: Aug 29, 2026
Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
[Clinical analysis of orbital histocytosis X]
Xiao-dong Zhou1, Guo-xiang Song, Yan-jin He
1Tianjin Orbit Institute, Department of Ophthalmology, The Second Affiliated Hospital, Tianjin Medical University, Tianjin 300211, China. zxdeye@sina.com
Objective:
To study the clinical and imaging features together with diagnosis and management of orbital histocytosis X.
Methods:
In a retrospective study from 1973 to 1999, 47 cases of histocytosis X were reviewed related with clinical materials, including eosinophilic granuloma 17 cases and Hand-Schuller- Christian disease 30 cases.
Results:
Most occur in children and teenagers, mainly in male. Characteristic clinical features, roentgenography, ultrasonography, CT, MRI provide the most diagnostic assistance.
Conclusions:
Solitary unifocal eosinophilic granuloma mainly involves teenagers. Hand-Schuller-Christian disease usually take places between birth and 5 years of age, which is characterized by multifocal variant of eosinophilic granuloma, especially the classic triad. Characteristic images contribute to the diagnosis. Multiple management is needed, including surgery, chemotherapy and radiotherapy. The prognosis varies with the three types.