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Selected genetic polymorphisms and plasma coagulation factor VII changes with exercise training.

Ioana A Ghiu1, Robert E Ferrell, Onanong Kulaputana

  • 1Department of Kinesiology, University of Maryland, College Park, MD 20742-2611, USA.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|February 10, 2004
PubMed
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Exercise training reduces coagulation factor VII (FVII) levels in older adults. These changes are linked to specific lipid-related gene variants, not FVII gene promoter variations.

Area of Science:

  • Exercise physiology
  • Genetics
  • Cardiovascular health

Background:

  • Coagulation factor VII (FVII) plays a role in blood clotting.
  • Gene polymorphisms and lipid profiles may influence FVII levels.
  • Exercise training is known to impact cardiovascular risk factors.

Purpose of the Study:

  • To investigate the impact of exercise training on FVII levels in middle- to older-aged adults.
  • To examine the association between FVII gene polymorphisms, lipid-related polymorphisms, and exercise-induced changes in FVII levels.
  • To determine if training-induced changes in plasma lipoprotein lipids mediate the relationship between genotypes and FVII changes.

Main Methods:

  • Forty-six healthy sedentary men and women participated.
  • Participants underwent a 6-month endurance exercise training program.

Related Experiment Videos

  • Measurements included plasma FVII-Ag levels, FVII gene polymorphisms, lipid-related polymorphisms (including apolipoprotein E and human ATPase binding cassette-1), and plasma lipoprotein lipids.

    • Main Results:

    • Plasma FVII-Ag levels significantly decreased following exercise training.
    • No significant differences in FVII-Ag changes were observed based on FVII gene promoter variants.
    • FVII-Ag changes with training were not correlated with changes in plasma lipoprotein lipids but were significantly associated with apolipoprotein E and human ATPase binding cassette-1 genotypes, even after adjusting for lipid changes.

    Conclusions:

    • Plasma FVII-Ag levels decrease with exercise training in middle- to older-aged adults.
    • Exercise-induced FVII changes are more strongly associated with specific lipid-related genotypes than with FVII gene promoter variants.
    • These findings suggest a genetic influence on how exercise impacts coagulation factor VII levels.