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Distribution of glomerular IgG subclass deposits in malignancy-associated membranous nephropathy
Hiroshi Ohtani1, Hideki Wakui, Atsushi Komatsuda
1The Third Department of Internal Medicine, Akita University School of Medicine, Hondo, Japan. Ohtanih@doc.med.akita-u.ac.jp
Background:
Several studies have shown a predominant glomerular deposition of IgG4 in patients with idiopathic membranous nephropathy (MN), whereas significant depositions of other IgG subclasses have been shown in patients with lupus-associated MN and bucillamine-induced MN.
Methods:
We examined the distribution patterns of glomerular IgG subclass deposits in 10 patients with malignancy-associated MN (M-MN) and in 15 patients with idiopathic MN by immunofluorescence (IF) microscopy.
Results:
The glomerular IF intensities of IgG1 and IgG2 were significantly stronger in the malignancy group than in the idiopathic group (P<0.05). In contrast, there were no differences in glomerular IF intensities of IgG3 and IgG4 between the two groups.
Conclusion:
Our findings suggest that the distribution patterns of glomerular IgG subclass deposits are different in idiopathic MN and M-MN. The strong IF intensity of glomerular IgG1 and IgG2 in M-MN may provide a possible predictor for this condition.
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