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Diisopropylphosphitocobalamin-acetone-water (1/3.48/7.56)
Susan M Chemaly1, Helder M Marques, Christopher B Perry
1Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, University of the Witwatersrand, PO Wits, Johannesburg 2050, South Africa. chemalysm@therapy.wits.ac.za
Acta Crystallographica. Section C, Crystal Structure Communications
|February 10, 2004
Summary
Diisopropylphosphite ligands coordinate to cobalt in cobalamin compounds via the phosphorus atom. This study details the crystal structure and Co-P bond length, contributing to understanding cobalamin chemistry.
Area of Science:
- Organometallic Chemistry
- Biochemistry
- Crystallography
Background:
- Cobalamins, vitamin B12 analogs, are crucial biomolecules.
- Phosphite ligands can coordinate to cobalt in cobalamin structures.
- Understanding coordination modes is key to cobalamin function.
Purpose of the Study:
- To characterize the crystal structure of diisopropylphosphitocobalamin.
- To determine the coordination environment and bond lengths.
- To discuss the structural trans influence in cobalamins.
Main Methods:
- X-ray crystallography
- Structural analysis of coordination compounds
- Comparison with known cobalamin structures
Main Results:
- The diisopropylphosphite ligand coordinates to the Co(III) atom through its phosphorus atom.
- The Co-P bond length was determined to be 2.227 (1) Å.
- The crystal structure is isomorphous with other cobalamins exhibiting packing type II.
Conclusions:
- The coordination of diisopropylphosphite to cobalamin is confirmed structurally.
- The determined Co-P bond length is consistent with other phosphitocobalamins.
- The findings contribute to the understanding of structural trans influence in cobalamins.