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Diisopropylphosphitocobalamin-acetone-water (1/3.48/7.56)
Susan M Chemaly1, Helder M Marques, Christopher B Perry
1Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, University of the Witwatersrand, PO Wits, Johannesburg 2050, South Africa. chemalysm@therapy.wits.ac.za
Abstract:
The diisopropylphosphite ligand in the title diisopropylphosphitocobalamin compound, [Co(C(68)H(102)N(13)O(17)P(2))].3.48C(3)H(6)O.7.56H(2)O, coordinates to the Co(III) atom via its P atom. The crystal structure is isomorphous with that of other cobalamins that adopt packing type II [Gruber, Jogl, Klintschar & Kratky (1998). Vitamin B(12) and B(12) Proteins, edited by Kräutler, Arigoni & Golding, pp. 335-347. New York: Wiley-VCH], with a Co-P bond length [2.227 (1) A] similar to that found in other phosphitocobalamins. The structural trans influence in cobalamins is discussed.