Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Twinning by merohedry in cyclohexanone oxime: a revised structure.

Martin Lutz1, Anthony L Spek, Reza Dabirian

  • 1Bijvoet Centre for Biomolecular Research, Department of Crystal and Structural Chemistry, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands. m.lutz@chem.uu.nl

Acta Crystallographica. Section C, Crystal Structure Communications
|February 10, 2004
PubMed
Summary

Crystal structure analysis of cyclohexanone oxime revealed severe disorder in the P3 space group. Re-investigation using merohedral twinning in the P-3 space group resolved the disorder, yielding a well-ordered structure.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structure and pH Dependence of Membranolytic Mechanisms by Truncated Oxidized Phospholipids.

Journal of the American Chemical Society·2025
Same author

Synergistic effects of oxidative and acid stress on bacterial membranes of Escherichia coli and Staphylococcus simulans.

Communications biology·2024
Same author

Two separate mechanisms are involved in membrane permeabilization during lipid oxidation.

Biophysical journal·2023
Same author

Synthesis and Evaluation of a Library of Alternating Amphipathic Copolymers to Solubilize and Study Membrane Proteins.

Biomacromolecules·2022
Same author

<i>checkCIF</i> validation ALERTS: what they mean and how to respond.

Acta crystallographica. Section E, Crystallographic communications·2020
Same author

A simple and convenient method for the hydrolysis of styrene-maleic anhydride copolymers to styrene-maleic acid copolymers.

Chemistry and physics of lipids·2018

Area of Science:

  • Crystallography
  • Solid-state chemistry
  • Molecular structure

Background:

  • The crystal structure of cyclohexanone oxime (C(6)H(11)NO) was previously reported with significant disorder.
  • The initial study identified the trigonal non-centrosymmetric space group P3.

Purpose of the Study:

  • To re-investigate and clarify the crystal structure of cyclohexanone oxime.
  • To resolve the reported severe disorder in the crystal lattice.
  • To determine the correct crystallographic space group and molecular arrangement.

Main Methods:

  • Crystal structure re-analysis using X-ray diffraction.
  • Application of merohedral twinning with a twofold rotation about [001] as the twin law.
  • Refinement in the trigonal centrosymmetric space group P-3.

Related Experiment Videos

Main Results:

  • The crystal structure was successfully refined in the centrosymmetric space group P-3, resolving the previous disorder.
  • Low R values indicate a high-quality, well-ordered structural model.
  • The asymmetric unit comprises three independent cyclohexanone oxime molecules.
  • These molecules form a hydrogen-bonded trimer, characterized by an R(3)(3)(9) graph set.

Conclusions:

  • Merohedral twinning is crucial for accurately determining the crystal structure of cyclohexanone oxime.
  • The corrected crystal structure reveals a well-ordered arrangement of hydrogen-bonded trimers.
  • This study provides a more accurate understanding of cyclohexanone oxime's solid-state behavior.