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Successful unrelated cord blood transplantation following reduced-intensity conditioning for refractory acute myeloid

Massimo Berger1, Elena Vassallo, Francesca Nesi

  • 1Department of Paediatrics, Regina Margherita Children's Hospital, University of Turin, Italy.

Journal of Pediatric Hematology/Oncology
|February 10, 2004
PubMed

Patients with relapsed acute myeloid leukemia following autograft have a poor prognosis. The possibility of allograft is frequently time-limited, as the disease reappears before a stem cell donor can be found in the worldwide registries. Cord blood transplantation is a new therapeutic approach, since cord blood units are rapidly available. The authors show how a relapsed chemotherapy-refractory patient was successful transplanted with a mismatched cord blood unit after reduced-intensity conditioning. Twenty-three months after transplantation, the child is in continuous complete remission and has full donor chimerism and no signs of chronic graft-versus-host disease.

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