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Related Experiment Videos

Sustained decrease in incidence of acute urinary retention and surgery with finasteride for 6 years in men with

Claus G Roehrborn1, Reginald Bruskewitz, J Curtis Nickel

  • 1The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9100, USA. Claus.Roehrborn@utsouthwestern.edu

The Journal of Urology
|February 10, 2004
PubMed
Summary

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Long-term finasteride treatment significantly reduced acute urinary retention and surgery for benign prostatic hyperplasia (BPH). These benefits were sustained over six years in men with enlarged prostates.

Area of Science:

  • Urology
  • Pharmacology

Background:

  • Benign prostatic hyperplasia (BPH) is a common condition in aging men.
  • Surgical intervention and acute urinary retention (AUR) are potential complications of BPH.

Purpose of the Study:

  • To evaluate the long-term efficacy of finasteride in reducing AUR and BPH-related surgery.
  • To assess the sustained effects of finasteride over a 6-year period.

Main Methods:

  • The Proscar Long-Term Efficacy and Safety Study (PLESS) involved 3040 men with symptomatic BPH.
  • Patients received either placebo or 5 mg finasteride daily for 4 years, followed by an optional 2-year open-label extension.
  • Outcomes included incidence of AUR and BPH-related surgery.

Main Results:

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  • Finasteride treatment sustained the reduction in AUR and/or BPH-related surgery over 6 years.
  • Men switching from placebo to finasteride in the extension phase showed similar outcomes to the continuous finasteride group.

    • Conclusions:

    • Six-year data from PLESS confirm finasteride's sustained efficacy in decreasing AUR and BPH-related surgery.
    • Finasteride is an effective long-term treatment option for men with BPH and enlarged prostates.