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Risk factors for retinopathy of prematurity requiring photocoagulation

Hiromi Ikeda1, Shoji Kuriyama

  • 1Department of Ophthalmology, Hyogo Prefectural Amagasaki Hospital, Hyogo, Japan. mikeda@osaka-u.ac.jp

Japanese Journal of Ophthalmology
|February 10, 2004
PubMed

Insights

Infection, indicated by C-reactive protein (CRP), increases the risk of retinopathy of prematurity (ROP) needing treatment. Blood transfusions and rescue surfactant also elevate the need for photocoagulation in preterm infants.

Area of Science:

  • Neonatal care and ophthalmology.
  • Perinatal medicine and critical care.

Background:

  • Retinopathy of prematurity (ROP) is a significant cause of visual impairment in preterm infants.
  • Birthweight and gestational age are established risk factors for ROP, but other factors also contribute.

Purpose of the Study:

  • To identify risk factors beyond birthweight and gestational age for ROP requiring photocoagulation in very low birthweight infants (BW < 1500 g).

Main Methods:

  • A retrospective analysis of 45 eyes with ROP was conducted.
  • Infants were categorized into three groups based on the extent of photocoagulation treatment received.
  • Maternal and neonatal factors were analyzed using multiple logistic regression.

Main Results:

  • Increased duration of infection, indicated by elevated C-reactive protein (CRP), was a significant risk factor for ROP requiring photocoagulation.
  • The number of days of infection and blood transfusions were significant predictors of ROP severity.
  • Use of rescue surfactant was strongly associated with the need for extensive photocoagulation.

Conclusions:

  • Routine monitoring of CRP levels is recommended for preterm infants to assess infection risk.
  • Blood transfusions and rescue surfactant use are associated with an increased probability of requiring photocoagulation for ROP.
Abstract

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