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Updated: Aug 13, 2026

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications
Published on: October 7, 2016
[Research of cross-linking reagent for producing hyaluronic acid derivative]
Jing-hua Chen1, Cong Lin, Qi-sheng Gu
1Shanghai Qisheng Biomaterial Institute, Shanghai, P. R. China 201106.
Objective:
To review the recent advances of cross-linking reagent for producing hyaluronic acid (HA) derivative so as to provide more advice for the development of HA reagent.
Methods:
Recent original articles related to the species, characteristic, cross-linking methodology and mechanism of the cross-linking reagent to producing HA derivative were summarized and systematically analyzed.
Results:
The derivatives after special kinds of reagents modification would remain their own good biocompatibility and change their original rheololgical characterization and obtain relative long organism residence time.
Conclusion:
Development of hyaluronic derivatives may widen their medical application.

