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Outcome in ischaemic stroke: carotid versus vertebro-basilar territory
G Popa1, A Nistorescu, A Stănescu
1Institute of Neurology and Psychiatry, Bucharest, Romania.
Insights
Vertebro-basilar ischaemic stroke (VBIS) shows male predominance and better outcomes compared to carotid ischaemic stroke (CIS). Mortality rates were similar, with myocardial infarction being a key cause of death in both stroke types.
Area of Science:
- Neurology
- Cardiovascular Medicine
- Clinical Research
Background:
- Ischaemic stroke is a leading cause of death and disability worldwide.
- Distinguishing between different stroke subtypes, such as carotid ischaemic stroke (CIS) and vertebro-basilar ischaemic stroke (VBIS), is crucial for understanding their unique characteristics and prognoses.
Purpose of the Study:
- To investigate and compare the clinical features, outcomes, and mortality of patients with CIS versus VBIS.
- To identify specific demographic and etiological differences between these two major ischaemic stroke classifications.
Main Methods:
- A clinical study and laboratory investigations were conducted.
- Data were collected from 166 patients with CIS and 64 patients with VBIS.
- Statistical analyses were performed to compare outcomes, including the modified Rankin Scale (MRS), and mortality rates.
Main Results:
- VBIS demonstrated a significant male predominance (p < 0.001).
- Patients with VBIS showed significantly better outcomes as assessed by the modified Rankin Scale (MRS) (p < 0.01).
- A significant number of different triggering factors were identified in VBIS patients (p < 0.001).
- No significant differences in mortality were observed between the CIS and VBIS groups (p > 0.05).
- Myocardial infarction was identified as a significant associated cause of death in both stroke types.
Conclusions:
- VBIS presents distinct epidemiological and clinical features compared to CIS.
- While VBIS may have a better functional outcome, mortality remains a concern, with cardiovascular events like myocardial infarction playing a critical role.
- Further research into specific risk factors and management strategies for VBIS is warranted.
Abstract:
Clinical study and laboratory investigations were performed in 166 carotid ischaemic stroke (CIS) patients and 64 vertebro-basilar ischaemic stroke (VBIS) patients. The study revealed some features of VBIS: significant male predominance (p < 0.001), better outcome (for modified Rankin Scale (MRS)) (p < 0.01), significant number of different triggering factors (p < 0.001). Nonsignificant differences in mortality were found in both groups (p > 0.05). Myocardial infarction was an important associated cause of death.