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Related Experiment Videos

Hypoglycemic effect of Ganoderma lucidum polysaccharides.

Hui-na Zhang1, Zhi-bin Lin

  • 1Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100083, China.

Acta Pharmacologica Sinica
|February 11, 2004
PubMed
Summary

Ganoderma lucidum polysaccharides (Gl-PS) effectively lower blood glucose in mice. This hypoglycemic effect is linked to Gl-PS stimulating insulin release by enhancing calcium ion influx into pancreatic beta cells.

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Area of Science:

  • Pharmacology
  • Endocrinology
  • Natural Products Research

Background:

  • Diabetes mellitus is a global health concern requiring novel therapeutic agents.
  • Traditional medicinal mushrooms like Ganoderma lucidum are explored for their potential health benefits.
  • Ganoderma lucidum polysaccharides (Gl-PS) are bioactive compounds with various reported pharmacological activities.

Purpose of the Study:

  • To evaluate the hypoglycemic effect of Ganoderma lucidum polysaccharides (Gl-PS) in normal fasted mice.
  • To elucidate the underlying mechanism of Gl-PS-induced hypoglycemia, focusing on insulin secretion and calcium signaling.

Main Methods:

  • Normal fasted mice were administered varying doses of Gl-PS (25, 50, 100 mg/kg) intraperitoneally.
  • Serum glucose and insulin levels were measured at multiple time points post-administration.

Related Experiment Videos

  • Pancreatic islets were isolated to assess insulin content, insulin release in response to glucose and Gl-PS, and intracellular calcium ([Ca2+]i) levels using confocal microscopy.

    • Main Results:

    • Gl-PS demonstrated a dose-dependent reduction in serum glucose levels at 3 and 6 hours.
    • A single dose of Gl-PS (100 mg/kg) significantly increased circulating insulin levels within 1 hour.
    • In vitro studies showed Gl-PS stimulated insulin release from pancreatic islets and increased intracellular calcium ([Ca2+]i), an effect inhibited by verapamil and egtazic acid.

    Conclusions:

    • Ganoderma lucidum polysaccharides (Gl-PS) exhibit a significant hypoglycemic effect in normal mice.
    • The mechanism involves Gl-PS-mediated stimulation of insulin release from pancreatic beta cells.
    • This insulin release is facilitated by enhanced calcium ion (Ca2+) influx into the pancreatic beta cells.