X-ray powder diffraction patterns for certain fluoroquinolone antibiotic drugs

Area of Science:

• Analytical Chemistry
• Crystallography
• Pharmaceutical Sciences

Background:

• Fluoroquinolone antibiotics are crucial antibacterial agents.
• Accurate identification of these drugs is essential for quality control and clinical use.
• Characterization of drug substances aids in understanding their physical properties.

Purpose of the Study:

• To obtain and present X-ray powder diffraction (XRD) data for six pure fluoroquinolone antibiotic drugs.
• To provide reference crystallographic information for ciprofloxacin, norfloxacin, enrofloxacin, ofloxacin, pefloxacin, and sparfloxacin.
• To facilitate the identification of these pharmaceutical compounds.

Main Methods:

• X-ray powder diffraction (XRD) was performed on pure samples of six fluoroquinolone antibiotics.
• Data acquisition covered a Bragg angle (2theta) range from 10 to 70 degrees.
• Lattice spacing (A) and relative line intensities (I/I(I)) were tabulated.

Main Results:

• XRD patterns were successfully generated for ciprofloxacin, norfloxacin, enrofloxacin, ofloxacin, pefloxacin, and sparfloxacin.
• Tabulated data include specific lattice spacing and relative line intensities for each drug.
• The generated data represent unique crystallographic fingerprints for these fluoroquinolones.

Conclusions:

• The obtained XRD data provide valuable new information for the identification of the studied fluoroquinolone antibiotics.
• This crystallographic dataset can serve as a reference for pharmaceutical analysis and quality assurance.
• The findings contribute to the characterization of important antibacterial drug substances.