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Updated: Aug 29, 2026

Detection and Isolation of Apoptotic Bodies to High Purity
12:17

Detection and Isolation of Apoptotic Bodies to High Purity

Published on: August 12, 2018

Biochemistry of apoptotic cell death

Karmela Barisić1, Jozsef Petrik, Lada Rumora

  • 1Department of Medical Biochemistry and Hematology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia. kbarisic@pharma.hr

Acta Pharmaceutica (Zagreb, Croatia)
|February 11, 2004
PubMed

Insights

Apoptosis, or programmed cell death, is vital for tissue health and homeostasis. Its dysregulation is linked to diseases like cancer, making its molecular components a therapeutic target.

Area of Science:

  • Cell Biology
  • Physiology
  • Molecular Biology

Background:

  • Apoptosis is a fundamental physiological process crucial for development and tissue maintenance.
  • Proper regulation of programmed cell death prevents uncontrolled cell proliferation and maintains organismal homeostasis.
  • Dysregulation of apoptosis is implicated in various pathologies, including cancer and neurodegenerative disorders.

Purpose of the Study:

  • To elucidate the critical role of apoptosis in physiological processes.
  • To highlight the connection between apoptosis dysregulation and disease pathogenesis.
  • To underscore the therapeutic potential of targeting apoptosis.

Main Methods:

  • Review of existing literature on apoptosis.
  • Analysis of gene and protein involvement in the apoptotic pathway.
  • Examination of disease states associated with apoptosis dysregulation.

Main Results:

  • Apoptosis requires coordinated action of specific regulatory and executor proteins.
  • Altered gene activity significantly impacts the initiation of cell self-destruction.
  • Numerous diseases share common features of apoptosis disregulation.

Conclusions:

  • Apoptosis is essential for normal development and tissue homeostasis.
  • Targeting key molecular components of apoptosis offers a promising therapeutic strategy for various diseases.
  • Understanding apoptosis mechanisms is critical for developing novel treatments.

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