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Neurological complication following tetanus toxoid immunization. A case report
B O Olutade1, A A Awotedu, C O Ukoli
1Department of Medicine, University College Hospital, Ibadan.
West African Journal of Medicine
|July 1, 1992
Summary
A Nigerian man experienced temporary neurological symptoms, including fever and muscle weakness, shortly after receiving a tetanus toxoid vaccine. These adverse events resolved within three days without further cause identified.
Area of Science:
- Neurology
- Immunology
- Vaccinology
Background:
- Tetanus toxoid vaccination is a critical public health intervention.
- Understanding potential adverse reactions is essential for vaccine safety monitoring.
Observation:
- A 33-year-old male presented with acute onset of fever, malaise, headache, muscle weakness, and polyneuropathy.
- These symptoms appeared 24 hours post-tetanus toxoid administration.
Findings:
- The patient's symptoms resolved spontaneously within 72 hours.
- No alternative etiological agents or predisposing factors were identified for the observed neurological manifestations.
Implications:
- This case highlights a possible transient neurological adverse event associated with tetanus toxoid vaccination.
- Further investigation may be warranted to elucidate the mechanism of this rare reaction.
- This underscores the importance of continued pharmacovigilance for vaccine safety.