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Brain natriuretic peptide in the management of heart failure: the versatile neurohormone
Simon de Denus1, Chantal Pharand, David R Williamson
1Philadelphia College of Pharmacy, University of Sciences of Philadelphia, Philadelphia, PA, USA.
Abstract:
Brain natriuretic peptide (BNP), also called B-type natriuretic peptide, is a member of a family of structurally related hormones, the natriuretic peptides. Current data suggest that measurement of BNP plasma concentrations is a useful tool in the diagnosis of acute heart failure in patients presenting to an emergency department with acute dyspnea. Furthermore, BNP constitutes a promising new marker of prognosis after an acute coronary syndrome episode and in patients with chronic heart failure. Nesiritide, the human recombinant form of BNP, is a new vasodilator used in the treatment of acute heart failure that has several potential advantages over current drug therapy.
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