Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Grading airway stenosis down to the segmental level using virtual bronchoscopy.

Hanno Hoppe1, Hans-Peter Dinkel, Beat Walder

  • 1Institute of Diagnostic Radiology , Division of Pulmonology, Inselspital, University of Berne, Freiburgstrasse 20, 3010 Berne, Switzerland. hanno.hoppe@web.de

Chest
|February 11, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Endovascular therapy for erectile dysfunction: insights from more than 1000 treatments.

CVIR endovascular·2026
Same author

Suspected Intracranial Angiolipoma With Cortical Cleft and Polymicrogyria in a Young Patient Presenting With First-Time Seizure: A Rare Triad in Neuroradiologic Imaging.

RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin·2026
Same author

Embolization therapy for pelvic arteriovenous malformations: a systematic review.

CVIR endovascular·2026
Same author

Endovascular therapy for erectile dysfunction: insights from more than 1000 treatments.

CVIR endovascular·2026
Same author

Midterm Outcomes of Venous Leak Embolization in Patients with Venogenic Erectile Dysfunction Unresponsive to Phosphodiesterase-5 Inhibitors.

Cardiovascular and interventional radiology·2025
Same author

Identification of morphological risk factors for sacroiliac joint syndrome using in vivo computed tomography-A comparative study.

PloS one·2025

Noninvasive virtual bronchoscopy using multirow detector CT shows high sensitivity for detecting airway stenosis. While effective for central airways, segmental airway stenosis detection had more false positives.

Area of Science:

  • Medical Imaging
  • Pulmonology
  • Diagnostic Technology

Background:

  • Airway stenosis diagnosis traditionally relies on invasive flexible bronchoscopy.
  • Noninvasive imaging modalities are sought to complement or replace invasive procedures.
  • Multirow detector CT (MDCT) offers potential for detailed airway visualization.

Purpose of the Study:

  • To evaluate the diagnostic accuracy of virtual bronchoscopy (VB) derived from MDCT.
  • To compare VB's sensitivity and specificity against flexible bronchoscopy (FB) for airway stenosis.
  • To assess VB's capability in grading central and segmental airway stenosis.

Main Methods:

  • A blinded controlled trial involving 20 patients with suspected airway stenosis.
  • MDCT scans acquired with 4 x 1 mm collimation for VB reconstruction.

Related Experiment Videos

  • FB served as the reference standard, with stenosis graded (0, 1, or 2) in 176 central and 302 segmental airway regions.

    • Main Results:

    • VB demonstrated high sensitivity (90.0%) for both central and segmental airway stenosis.
    • Specificity was high for central (96.6%) and segmental (95.6%) airways.
    • VB showed higher false-positive rates and lower positive predictive value in segmental airways compared to central airways.

    Conclusions:

    • MDCT-based VB is a sensitive, noninvasive tool for detecting central and segmental airway stenosis.
    • VB provides high-resolution endoluminal airway imaging down to segmental bronchi.
    • Careful interpretation is needed for segmental airway stenosis due to a higher false-positive rate.