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Updated: Aug 4, 2026

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
Total synthesis of (+)-tanikolide via oxidative lactonization
Jennifer M Schomaker1, Babak Borhan
1Department of Chemistry, Michigan State University, East Lansing, MI 48824, USA. borhan@cem.msu.edu
Abstract:
(+)-Tanikolide has been synthesized in eight linear steps with a 31% overall yield. The key step in the synthesis utilizes a recently developed tandem oxidative cleavage-lactonization of a precursor alkenol to deliver the lactone moiety.
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