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Updated: Jul 22, 2026

Assaying the Ability of Diffusible Signaling Molecules to Reorient Embryonic Spinal Commissural Axons
Published on: March 8, 2010
Biological functions and signaling of a transmembrane semaphorin, CD100/Sema4D
1Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan.
Abstract:
The semaphorin proteins were identified originally as axonal guidance factors functioning during neuronal development. In addition to this function, several semaphorins play diverse roles outside the nervous system. The class 4 semaphorin CD100/Sema4D, which utilizes plexin-B1 and CD72 as receptors, exerts important biological effects on a variety of cells, including the neuronal, epithelial and immune cells. Here, we review recent advances exploring the molecular mechanisms governing the biological functions of CD100/Sema4D.
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