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Related Experiment Videos

Computed tomographic correlation with pituitary function in Sheehan's syndrome.

H C Lee1, E J Lee, K W Lee

  • 1Department of Internal Medicine, College of Medicine, Yonsei University, Seoul, Korea.

The Korean Journal of Internal Medicine
|January 1, 1992
PubMed
Summary
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High-resolution computed tomography (CT) in Sheehan's syndrome reveals that the amount of pituitary remnants in the sella turcica correlates with remaining pituitary function. More pituitary tissue visualized by CT indicates better hormonal reserve.

Area of Science:

  • Endocrinology
  • Radiology
  • Reproductive Medicine

Background:

  • Sheehan's syndrome is a critical condition characterized by postpartum pituitary necrosis.
  • Assessing residual pituitary function is crucial for managing patients with Sheehan's syndrome.

Purpose of the Study:

  • To correlate high-resolution computed tomography (CT) findings of the sella turcica with pituitary reserve functions in patients with Sheehan's syndrome.

Main Methods:

  • Twenty-six patients with Sheehan's syndrome underwent high-resolution CT and sequential pituitary stimulation tests.
  • CT imaging assessed the sella turcica for empty sella (completely or partially) or normal appearance.
  • Hormonal reserve was evaluated through various stimulation tests.

Main Results:

Related Experiment Videos

  • CT revealed 21 cases of completely empty sella (CES) and 4 of partially empty sella (PES).
  • Panhypopituitarism was more common in CES (20/21) than PES (1/4).
  • Preserved pituitary remnants visualized by CT correlated with better preservation of TSH, cortisol, FSH, and LH secretory capacity.

Conclusions:

  • The extent of pituitary remnants, as detected by CT, is a significant indicator of hormonal secretory capacity in Sheehan's syndrome.
  • CT findings of the sella turcica can help predict the degree of pituitary dysfunction and guide management.