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Lithium in combination with perphenazine: effect on plasma monoamine metabolites
M B Bowers1, C M Mazure, J C Nelson
1Department of Psychiatry, Yale University School of Medicine, New Haven, CT.
Biological Psychiatry
|December 25, 1992
Abstract:
The addition of lithium to perphenazine altered the pattern of plasma homovanillic acid (HVA) during the course of treatment for acute psychosis. In the perphenazine-treated group plasma HVA declined significantly by days 7-9 of treatment, whereas in the perphenazine-plus-lithium group plasma HVA tended to increase. The pattern for plasma methoxyhydroxyphenethyl-glycol (MHPG) was not significantly different for the two groups. The addition of lithium to a neuroleptic may enhance the metabolism of dopamine.