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Renal impairment probably induced by etretinate
1Clinique Dermatologique, Hôpitaux Universitaires de Strasbourg, France.
Dermatology (Basel, Switzerland)
|January 1, 1992
Summary
An 83-year-old patient experienced acute renal impairment while taking etretinate for pityriasis rubra pilaris. Kidney function returned to normal after discontinuing the medication, suggesting etretinate may cause kidney issues.
Area of Science:
- Nephrology
- Dermatology
Background:
- Pityriasis rubra pilaris (PRP) is a rare chronic skin disorder.
- Retinoids are commonly used in dermatology for various skin conditions.
Observation:
- An 83-year-old male patient with PRP was treated with etretinate 70 mg daily.
- The patient developed acute renal impairment, evidenced by creatinine levels rising to 73 mg/l by day 7.
Findings:
- Discontinuation of etretinate led to the complete reversal of all observed biological changes, including renal function.
- While not a recognized side effect, the temporal relationship strongly suggests etretinate's role in the renal impairment.
Implications:
- This case highlights a potential, albeit rare, adverse effect of etretinate on renal function.
- Further investigation may be warranted to understand the mechanism and prevalence of etretinate-induced nephrotoxicity.