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Fixed drug eruption of the scrotum due to methylphenidate
H A Cohen1, A Ashkenazi, M Nussinovitch
1Department of Pediatrics, Hasharon Hospital, Sackler School of Medicine, Tel Aviv University, Petach Tikvah, Israel.
Objective:
To report two cases of fixed drug eruption induced by methylphenidate.
Case Summary:
Two children with attention deficit disorder treated with methylphenidate as a simple drug developed fixed drug eruption of the scrotum. Drug discontinuation was followed by a complete resolution of the skin eruption. Rechallenge resulted in the same drug rash. Macrophage migration-inhibiting factor (MIF) assay with methylphenidate was positive.
Discussion:
The pathogenesis of fixed drug eruption and the role of MIF assay in the diagnosis of adverse drug reaction is discussed.
Conclusions:
Fixed drug rash induced by methylphenidate is a possible but rare phenomenon.