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Current treatment recommendations for leishmaniasis.

J T Moss1, J P Wilson

  • 1Pharmacy Branch, Academy of Health Sciences, Ft. Sam Houston, TX.

The Annals of Pharmacotherapy
|November 1, 1992
PubMed
Summary
This summary is machine-generated.

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Leishmaniasis presents variably, with treatment often relying on antimonial drugs. Emerging resistance and toxicity necessitate exploring alternative therapies for this infectious disease.

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Parasitology

Background:

  • Leishmaniasis is a parasitic disease transmitted by sandflies.
  • Its epidemiology and clinical manifestations vary significantly worldwide.
  • Southwest Asia is an endemic region with specific disease characteristics.

Purpose of the Study:

  • To comprehensively review leishmaniasis epidemiology.
  • To detail clinical presentations and risk factors.
  • To examine pathogenesis and current treatment strategies.

Main Methods:

  • Literature review of infectious disease publications.
  • Analysis of subject reviews, case reports, and clinical trials.
  • Focus on Southwest Asian leishmaniasis, pathogenesis, and management.

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Main Results:

  • Leishmaniasis exhibits diverse clinical presentations.
  • Parenteral antimonial drugs are primary treatments but face resistance and toxicity.
  • Alternative treatments include heat, surgery, and various antimicrobial/immunotherapies.

Conclusions:

  • Leishmaniasis cases in the US are historically low but may increase due to returning military personnel.
  • Medical professionals, especially in governmental settings, need awareness of leishmaniasis.
  • Familiarity with pathogenesis and treatment options is crucial for managing this infection.