Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The prefrontal cortex and internally generated motor acts.

P S Goldman-Rakic1, J F Bates, M V Chafee

  • 1Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510.

Current Opinion in Neurobiology
|December 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Enhancement of metabolic activity in the diencephalon of monkeys performing working memory task: a 2-deoxyglucose study in behaving rhesus monkeys.

Journal of cognitive neuroscience·2013
Same author

Masticatory function-a review of the literature: (II) Speed of movement of the mandible, rate of chewing and forces developed in chewing.

Journal of oral rehabilitation·2012
Same author

Antipsychotics and working memory in schizophrenia.

Science (New York, N.Y.)·2007
Same author

Morphometric characterization of synapses in the primate prefrontal cortex formed by afferents from the mediodorsal thalamic nucleus.

Experimental brain research·2005
Same author

Differential anterior prefrontal activation during the recognition stage of a spatial working memory task.

Cerebral cortex (New York, N.Y. : 1991)·2005
Same author

Division of labor among distinct subtypes of inhibitory neurons in a cortical microcircuit of working memory.

Proceedings of the National Academy of Sciences of the United States of America·2004
Same journal

Population codes for context-dependent decision-making.

Current opinion in neurobiology·2026
Same journal

Cichlid fish as a model for understanding social dysfunction.

Current opinion in neurobiology·2026
Same journal

On aims and methods in field neuroethology: Investigating neural mechanisms of behavior in semi-natural and natural contexts.

Current opinion in neurobiology·2026
Same journal

Neurobiological interfaces connecting environmental change to monarch butterfly migration.

Current opinion in neurobiology·2026
Same journal

Learning how to experience the world: From circuits to cell types to genes.

Current opinion in neurobiology·2026
Same journal

Editorial overview for neurobiology of disease 2026.

Current opinion in neurobiology·2026
See all related articles

New research framework reveals how prefrontal cortex influences motor output by distinguishing memory-based from sensory-based functions. This integrates prefrontal, premotor, and subcortical roles in motor control.

Area of Science:

  • Neuroscience
  • Motor Control
  • Primate Neuroanatomy
  • Neurophysiology

Background:

  • Understanding the neural basis of motor control is crucial for addressing motor disorders.
  • Previous research has implicated various brain regions in motor output, but a unified framework is lacking.
  • Experimental primate studies provide valuable insights into brain function.

Purpose of the Study:

  • To develop a framework for understanding prefrontal cortex influence on motor output.
  • To differentiate between internally memory-based and externally sensory-based motor functions.
  • To integrate the roles of prefrontal, premotor, and subcortical structures in motor control.

Main Methods:

  • Analysis of neuroanatomical data from experimental primates.

Related Experiment Videos

  • Analysis of neurophysiological data from experimental primates.
  • Development of a computational or conceptual framework based on collected data.

    • Main Results:

    • A framework has been established that distinguishes memory-based functions (linked to prefrontal circuits) from sensory-based functions (linked to premotor circuits).
    • The framework highlights the specialized contributions of prefrontal, premotor, and subcortical structures.
    • Integration of these specialized structures is shown to be critical for the control of motor acts.

    Conclusions:

    • The proposed framework offers a unified understanding of how the prefrontal cortex modulates motor output.
    • This framework elucidates the distinct yet integrated roles of different neural circuits in motor control.
    • Further research can build upon this framework to explore therapeutic strategies for motor impairments.