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Systemic absorption of ocular cyclopentolate in children
K Lahdes1, R Huupponen, T Kaila
1Department of Ophthalmology, University of Turku, Finland.
German Journal of Ophthalmology
|January 1, 1992
Summary
Ocular cyclopentolate eye drops are absorbed into the bloodstream in children, leading to pupil dilation. Systemic absorption of cyclopentolate varied significantly among individuals, but did not affect heart rate.
Area of Science:
- Ophthalmology
- Pharmacology
- Pediatrics
Background:
- Cyclopentolate is an anticholinergic medication used to dilate pupils for eye examinations.
- Systemic absorption and effects of ocular cyclopentolate in children require further investigation.
Purpose of the Study:
- To quantify cyclopentolate plasma levels after ocular administration in children.
- To monitor heart rate and pupil size changes following topical cyclopentolate application.
Main Methods:
- A randomized, placebo-controlled study involving 12 children.
- Administration of a single 35-microliters eyedrop of 1% cyclopentolate or placebo.
- Quantification of plasma cyclopentolate concentrations using a sensitive radioreceptor assay.
Main Results:
- Detectable cyclopentolate plasma concentrations were observed in most children within 3 minutes of ocular application.
- Significant interindividual variability in peak plasma cyclopentolate levels (median 2.9 ng/ml, range undetectable to 5.8 ng/ml).
- Cyclopentolate significantly increased pupillary diameter but did not alter heart rate.
Conclusions:
- Ocular cyclopentolate is systemically absorbed in children, with considerable interindividual variation.
- The drug effectively induces mydriasis without affecting heart rate in pediatric subjects.
- Further research is warranted to understand the clinical implications of systemic cyclopentolate absorption in children.