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Pseudoexfoliation syndrome and glaucoma. Does glaucoma capsulare exist?

J Wollensak1, H U Becker, T Seiler

  • 1Universitäts-Augenklinik im Klinikum Charlottenburg, Freie Universität, Berlin, Federal Republic of Germany.

German Journal of Ophthalmology
|January 1, 1992
PubMed
Summary

Pseudoexfoliation syndrome (PES) is a condition with material deposits in the eye. This study found no statistically significant difference in glaucoma prevalence between PES patients and controls.

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Area of Science:

  • Ophthalmology
  • Genetics

Background:

  • Pseudoexfoliation syndrome (PES) involves characteristic material deposition in the anterior eye segment.
  • A high frequency of associated glaucoma has been reported in PES patients.
  • The precise mechanisms linking PES and glaucoma remain unclear.

Purpose of the Study:

  • To investigate the prevalence of glaucoma in patients with pseudoexfoliation syndrome.
  • To determine if there is a statistically significant association between PES and glaucoma.

Main Methods:

  • A cohort of 5154 patients undergoing cataract extraction was analyzed.
  • Prevalence of PES and glaucoma was determined in this cohort.
  • An age-matched control group was used for comparison.

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Main Results:

  • The prevalence of PES was 6.1% (314 patients).
  • Glaucoma was diagnosed in 16.2% of PES patients versus 10.9% in the control group.
  • The difference in glaucoma prevalence between PES patients and controls was not statistically significant.

Conclusions:

  • The findings do not support the existence of a distinct clinical entity termed "glaucoma capsulare."
  • Further research is needed to clarify the relationship between PES and glaucoma.
  • The study highlights the importance of careful glaucoma screening in all patients, regardless of PES status.