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Total intravenous anesthesia with a continuous propofol-alfentanil infusion
CRNA : the Clinical Forum for Nurse Anesthetists
|August 1, 1992
Summary
Total intravenous anesthesia with propofol and alfentanil offers similar recovery times to balanced anesthesia. Hemodynamic stability was improved, but amnesia requires additional agents for propofol-based anesthesia.
Area of Science:
- Anesthesiology
- Pharmacology
Background:
- Balanced anesthesia traditionally uses inhalation agents like isoflurane.
- Total intravenous anesthesia (TIVA) with propofol offers an alternative anesthetic approach.
Purpose of the Study:
- To compare the recovery room stay duration between TIVA (propofol/alfentanil) and balanced anesthesia (isoflurane/alfentanil).
Main Methods:
- Forty-three adult patients received either propofol/alfentanil TIVA or isoflurane/alfentanil balanced anesthesia.
- Recovery was assessed via pain, verbal fluency, and short-term memory tests.
Main Results:
- No significant differences in recovery rates at 30 or 60 minutes postextubation were observed.
- Propofol group showed slightly better hemodynamic stability during induction and intubation.
- One instance each of intraoperative awareness and delayed eye opening occurred in the propofol group.
Conclusions:
- TIVA with propofol and alfentanil is as effective as balanced anesthesia with comparable recovery.
- Caution is advised regarding the amnestic properties of propofol when used as the sole anesthetic agent.