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Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock
16:31

Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock

Published on: June 6, 2011

Organ damage in shock, disseminated intravascular coagulation, and stroke

R M Hardaway1

  • 1Dept. of Surgery, Texas Tech University, School of Medicine, El Paso 79906.

Comprehensive Therapy
|November 1, 1992
PubMed

Insights

Disseminated intravascular coagulation (DIC) can cause organ failure. Fibrinolytic therapy shows promise in restoring blood flow and preventing organ damage, potentially aiding stroke treatment.

Area of Science:

  • Medical Science
  • Hematology
  • Critical Care Medicine

Background:

  • Disseminated intravascular coagulation (DIC) is a serious condition that can lead to multiple organ failure due to capillary occlusion.
  • The lungs, liver, kidneys, gut, heart, and brain are particularly vulnerable to DIC-induced damage, including focal brain necrosis.

Purpose of the Study:

  • To evaluate the efficacy of fibrinolytic therapy in restoring blood flow to capillaries affected by DIC.
  • To explore the potential of fibrinolytic agents in preventing organ failure and treating other forms of intravascular coagulation, such as stroke.

Main Methods:

  • Administration of fibrinolytic therapy, often in low intravenous doses over 24 hours.
  • Monitoring of blood flow restoration, organ function (lungs, liver, kidneys), and coagulation mechanisms.

Main Results:

  • Fibrinolytic therapy successfully restored significant blood flow to lung capillaries, leading to improved lung function.
  • Early administration of fibrinolytic therapy (within four hours of trauma) prevented liver and kidney failure.
  • Low-dose intravenous fibrinolytic therapy showed minimal impact on the coagulation mechanism, with no significant bleeding concerns.

Conclusions:

  • Fibrinolytic therapy is effective in restoring capillary blood flow and preventing organ damage in DIC.
  • The findings suggest that plasminogen activators may be a viable treatment for intravascular coagulation in the brain, including stroke.

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