Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Is diabetes always diabetes?

A Akinmokun1, P Harris, P D Home

  • 1Department of Medicine, University of Newcastle upon Tyne, Medical School, UK.

Diabetes Research and Clinical Practice
|November 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A double blind study of the effect of acipimox on serum lipids, blood glucose control and insulin action in non-obese patients with type 2 diabetes mellitus.

Diabetic medicine : a journal of the British Diabetic Association·1992
Same author

A survey of lower limb amputation in diabetic patients.

Diabetic medicine : a journal of the British Diabetic Association·1992
Same author

Metabolic effects of suppression of nonesterified fatty acid levels with acipimox in obese NIDDM subjects.

Diabetes·1992
Same author

The effects of human proinsulin on glucose turnover and intermediary metabolism in insulin-dependent-diabetes mellitus.

The Journal of clinical endocrinology and metabolism·1992
Same author

Is diabetes mellitus related to undernutrition in rural Tanzania?

BMJ (Clinical research ed.)·1992
Same author

Diabetes is not caused by cassava toxicity. A study in a Tanzanian community.

Diabetes care·1992
Same journal

Independent and combined effects of first-trimester elevated fasting blood glucose and high-normal blood pressure on pregnancy outcomes.

Diabetes research and clinical practice·2026
Same journal

Baseline levels and dynamic trajectories of fasting C peptide to blood glucose ratio predict the risk of combined vascular damage in type 2 diabetes: a longitudinal cohort study.

Diabetes research and clinical practice·2026
Same journal

Optimal screening practices for diabetic retinopathy in children and adolescents with type 1 diabetes: a systematic review to inform global screening guidance.

Diabetes research and clinical practice·2026
Same journal

GLP-1 receptor agonists in pediatric obesity and diabetes: a systematic review of efficacy, metabolic effects, and safety.

Diabetes research and clinical practice·2026
Same journal

Corrigendum to "Relationship between severe hypoglycemia or impaired awareness of hypoglycemia and diabetes-related health status, global cognition and executive functions in adults with type 1 diabetes without severe anxiety or depression" [Diabetes Res Clin Pract 221 (2025) 112004. doi: 10.1016/j.diabres.2025.112004. Epub2025 Jan 11. PMID:39805380].

Diabetes research and clinical practice·2026
Same journal

Macular microcirculation changes in incident type 2 diabetes without fundus Photography-Detectable diabetic Retinopathy: A 6-Year nested Case-Control study.

Diabetes research and clinical practice·2026
See all related articles

Many people with diabetes can achieve normal glucose tolerance through diet and weight loss, challenging the lifelong diagnosis. This suggests a review of diabetes diagnostic criteria is needed for those maintaining healthy habits.

Area of Science:

  • Endocrinology
  • Metabolic Diseases
  • Clinical Nutrition

Background:

  • Diabetes mellitus is typically considered a lifelong condition.
  • Lifestyle interventions, including diet and weight loss, are cornerstones of diabetes management.
  • The potential for remission or reversal of diabetes requires further investigation.

Purpose of the Study:

  • To investigate the possibility of reversing or achieving remission in patients diagnosed with diabetes.
  • To re-examine the concept of diabetes as a strictly lifelong diagnosis.
  • To assess glucose tolerance and glycemic control in diabetic patients who have undergone significant weight loss through dietary changes.

Main Methods:

  • Oral glucose tolerance tests (OGTT) were administered twice to 37 patients with a history of diabetes.

Related Experiment Videos

  • Patients had normal glycosylated hemoglobin (HbA1c) levels and a mean diabetes duration of 4.6 years.
  • Weight loss, dietary intake, and HbA1c levels were recorded and analyzed in relation to OGTT results.

    • Main Results:

    • Normal glucose tolerance was observed in 27% of patients, and impaired glucose tolerance in 21%.
    • Glycosylated hemoglobin (HbA1c) levels were significantly lower in patients with normal glucose tolerance compared to those with impaired glucose tolerance (P < 0.05).
    • The response to OGTT varied with dietary intake and weight, indicating reversibility in some individuals.

    Conclusions:

    • A subset of patients with previously diagnosed diabetes can achieve normal glucose tolerance through sustained lifestyle modifications.
    • The findings challenge the notion of diabetes as an irreversible, lifelong diagnosis for all individuals.
    • A review of the definition of diabetes is recommended to accommodate remission in patients who establish permanent healthy dietary habits.