Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Electrophysiology of Normal Cardiac Rhythm01:19

Electrophysiology of Normal Cardiac Rhythm

7.8K
The normal cardiac rhythm is a synchronized electrical activity that facilitates the regular and coordinated contraction of the heart muscle. This process is essential for efficient blood circulation throughout the body. The fundamental elements involved in establishing and maintaining this rhythm include the unique electrical properties of cardiac muscle cells, the sinoatrial (SA) node's pacemaker function, the specialized conducting system, and the ionic mechanisms underlying each phase...
7.8K
Conduction System of the Heart01:19

Conduction System of the Heart

13.7K
Autorhythmicity is a term that refers to the heart's inherent ability to generate electrical signals and instigate muscle contractions. This self-regulating conduction system within the heart consists of two key components: the pacemaker cells and specialized conducting cells.
The pacemaker cells are located in two primary nodes: the sinoatrial (SA) node and the atrioventricular (AV) node. The SA node pacemaker cells can autonomously depolarize, triggering an action potential that leads to the...
13.7K
Conduction System of the Heart01:20

Conduction System of the Heart

6.1K
The cardiac conduction system produces and transmits electrical impulses that prompt myocardial contraction, ensuring efficient heart function. This intricate system ensures that the heart beats in a coordinated and efficient manner, beginning with the atria and then the ventricles. The conduction system optimizes cardiac output by maintaining this precise sequence, which is crucial for adequate blood circulation.
This system relies on the unique properties of nodal and Purkinje cells:...
6.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intracortical BCI Performance is Robust to Changes in Attentional Load During Dual-Tasking.

bioRxiv : the preprint server for biology·2026
Same author

Expert-Level Detection of Epilepsy Markers in EEG on Short and Long Timescales.

NEJM AI·2025
Same author

Awareness of bone strength in patients with neuromuscular disorders: ERN EURO-NMD clinician survey and European patient survey.

Journal of the neurological sciences·2025
Same author

Building consensus on clinical outcome assessments for BCI devices. A summary of the 10th BCI society meeting 2023 workshop.

Journal of neural engineering·2024
Same author

Fecal Microbiota Transfer in Acute Graft-versus-Host Disease following Allogeneic Stem Cell Transplantation.

Visceral medicine·2024
Same author

Randomized phase-III study of low-dose cytarabine and etoposide + /- all-trans retinoic acid in older unfit patients with NPM1-mutated acute myeloid leukemia.

Scientific reports·2023
Same journal

The surgical collateralization theory: has the beautiful hypothesis been killed by the ugly facts?

European heart journal·2026
Same journal

Beyond single measurement: additional considerations for high-sensitivity C-reactive protein in cardiovascular risk prediction.

European heart journal·2026
Same journal

Brain mineralocorticoid receptor activation and antagonism in heart failure with preserved ejection fraction: a hypothesis.

European heart journal·2026
Same journal

Myths and misconceptions about high-sensitivity C-reactive protein as a marker of residual inflammatory risk.

European heart journal·2026
Same journal

Vascular Ehlers-Danlos syndrome: should we treat asymptomatic patients?

European heart journal·2026
Same journal

Impactful trials on dyslipidaemias, fractional flow reserve, beta-blockers, and peripheral artery disease.

European heart journal·2026
See all related articles

Related Experiment Video

Updated: May 6, 2026

Cardiac Pressure-Volume Loop Analysis Using Conductance Catheters in Mice
08:15

Cardiac Pressure-Volume Loop Analysis Using Conductance Catheters in Mice

Published on: September 17, 2015

18.9K

Right ventricular conductance to establish closed-loop pacing.

M Schaldach1, E Ebner, H Hutten

  • 1Zentralinstitut für Biomedizinische Technik, Universität Erlangen-Nürnberg, Germany.

European Heart Journal
|November 1, 1992
PubMed
Summary
This summary is machine-generated.

This study introduces a new pacemaker algorithm that uses autonomic nervous system (ANS) signals to adjust heart rate, improving quality of life for patients with sick sinus syndrome.

More Related Videos

Cardiac Response to β-Adrenergic Stimulation Determined by Pressure-Volume Loop Analysis
08:05

Cardiac Response to β-Adrenergic Stimulation Determined by Pressure-Volume Loop Analysis

Published on: May 19, 2021

2.5K
Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach
07:49

Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach

Published on: July 21, 2023

2.0K

Related Experiment Videos

Last Updated: May 6, 2026

Cardiac Pressure-Volume Loop Analysis Using Conductance Catheters in Mice
08:15

Cardiac Pressure-Volume Loop Analysis Using Conductance Catheters in Mice

Published on: September 17, 2015

18.9K
Cardiac Response to β-Adrenergic Stimulation Determined by Pressure-Volume Loop Analysis
08:05

Cardiac Response to β-Adrenergic Stimulation Determined by Pressure-Volume Loop Analysis

Published on: May 19, 2021

2.5K
Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach
07:49

Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach

Published on: July 21, 2023

2.0K

Area of Science:

  • Biomedical Engineering
  • Cardiology
  • Physiology

Background:

  • Sick sinus syndrome impairs heart rate regulation.
  • Current pacemakers may not fully restore physiological heart rate control.
  • Autonomic nervous system (ANS) plays a crucial role in heart rate modulation.

Purpose of the Study:

  • To develop and evaluate a novel pacemaker algorithm for rate-adaptive cardiac pacing.
  • To restore physiological closed-loop chronotropic control using ANS information.
  • To improve the quality of life for patients with heart rhythm disorders.

Main Methods:

  • Extraction of ANS control information from myocardial contractile performance using unipolar conductance measurements.
  • Development of the regional effective slope quantity (RQ) algorithm to isolate the ANS signal.
  • Normalization of the ANS signal into the ventricular inotropic parameter (VIP).

Main Results:

  • The VIP parameter effectively represents ANS inotropic signals to the myocardium.
  • Multi-center studies demonstrated close correlation between ANS-controlled pacing rate and spontaneous sinus rate.
  • Patients showed improved cardiovascular circulation control, evidenced by blood pressure and subjective reports.

Conclusions:

  • The developed ANS control concept and VIP parameter enable effective rate-adaptive cardiac pacing.
  • This technology holds promise for significantly improving patient quality of life.
  • Further evaluation in patients with AV block confirmed the efficacy of VIP-controlled pacemakers.