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Related Experiment Video

Updated: Jun 26, 2026

Cardiac Catheterization in Mice to Measure the Pressure Volume Relationship: Investigating the Bowditch Effect

Cardiac Catheterization in Mice to Measure the Pressure Volume Relationship: Investigating the Bowditch Effect

Published on: June 14, 2015

Ventricular pressure-volume relations in vivo.

J Baan¹, E T van der Velde, P Steendijk

¹Department of Cardiology, Leiden University Hospital, The Netherlands.

European Heart Journal

|November 1, 1992

Summary

This study explores cardiac muscle mechanics, including Starling's law and contractility. It proposes a new method using end-systolic volume to assess left ventricular function after interventions.

Area of Science:

Cardiology
Biomedical Engineering
Physiology

Background:

Cardiac muscle exhibits complex mechanical properties influencing ventricular function.
Understanding these properties is crucial for diagnosing and treating heart conditions.

Purpose of the Study:

To discuss fundamental mechanical properties of cardiac muscle and the ventricle.
To propose a novel parameter for characterizing myocardial contractility.

Main Methods:

Discussion of Starling's law, shortening deactivation, and homeometric autoregulation.
Analysis of the load-dependence of the end-systolic pressure-volume relationship (ESPVR).

Main Results:

The ESPVR's load-dependence is explained by shortening deactivation and homeometric autoregulation.

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Published on: June 14, 2015

Cardiac Pressure-Volume Loop Analysis Using Conductance Catheters in Mice

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Published on: September 17, 2015

Closed Chest Biventricular Pressure-Volume Loop Recordings with Admittance Catheters in a Porcine Model

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A new definition of myocardial contractility is derived from parallel ESPVR shifts.

The left ventricle increases its inotropic state in response to increased afterload.

Conclusions:

A proposed method uses end-systolic volume at a constant end-systolic pressure to quantify myocardial contractility changes.
This parameter can characterize post-intervention changes in patients.