Related Experiment Video

Updated: May 12, 2026

Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure
09:37

Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure

Published on: December 2, 2014

Left ventricular filling after long-term angiotensin converting enzyme inhibition in congestive heart failure

L H Baur1, J J Schipperheyn, V M Cats

  • 1Department of Cardiology, University Hospital Leiden, The Netherlands.

European Heart Journal
|November 1, 1992
PubMed

Insights

Enalapril improved cardiac remodeling in heart failure patients by reducing ventricular dilation and stiffness. However, it did not significantly alter early diastolic relaxation parameters.

Area of Science:

  • Cardiology
  • Pharmacology
  • Heart Failure Research

Background:

  • Left ventricular relaxation is often impaired in patients with coronary artery disease and congestive heart failure.
  • Ventricular dilation alters passive elastic properties in diastole, impacting overall heart function.

Purpose of the Study:

  • To investigate the effects of enalapril on left ventricular diastolic properties in patients with congestive heart failure.
  • To assess changes in diastolic function and ventricular stiffness following enalapril treatment.

Main Methods:

  • Studied 11 patients with congestive heart failure (NYHA class II-IV) before and after 3 months of enalapril therapy.
  • Utilized radionuclide angiography and simultaneous pressure-volume measurements for hemodynamic assessment.
  • Analyzed systemic vascular resistance, left ventricular end-diastolic pressure, and end-diastolic volume index.

Main Results:

  • Enalapril significantly reduced systemic vascular resistance and left ventricular end-diastolic pressure.
  • Left ventricular end-diastolic volume index decreased significantly, indicating regression of ventricular dilation.
  • Early diastolic relaxation indices (peak filling rate, time to peak filling rate, peak negative dP/dt, tau) showed no significant change.
  • Increased diastolic pressure-volume relationship steepness indicated enhanced chamber stiffness, primarily due to geometric changes.

Conclusions:

  • Enalapril-induced regression of cardiac remodeling in heart failure patients improves ventricular geometry and reduces chamber stiffness.
  • These geometric improvements do not significantly alter intrinsic early diastolic relaxation parameters.
  • The study highlights the impact of reverse remodeling on diastolic function beyond direct effects on relaxation mechanisms.

More Related Videos

Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs14:35

Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs

Published on: April 17, 2021

Transthoracic Echocardiography to Assess Post-Resuscitation Left Ventricular Dysfunction After Acute Myocardial Infarction and Cardiac Arrest in Pigs08:19

Transthoracic Echocardiography to Assess Post-Resuscitation Left Ventricular Dysfunction After Acute Myocardial Infarction and Cardiac Arrest in Pigs

Published on: July 12, 2022

Related Concept Videos

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Heart Failure V: Medical Management01:30

Heart Failure V: Medical Management

Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...