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Human dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR
D J Vandenbergh1, A M Persico, A L Hawkins
1Laboratory of Molecular Neurobiology, National Institute on Drug Abuse, Baltimore, MD 21224.
Genomics
|December 1, 1992
Abstract:
The human dopamine transporter (DAT1) gene is localized to chromosome 5p15.3 by in situ hybridization and PCR amplification of rodent somatic cell hybrid DNA. Analysis of a 40-bp repeat in the 3' untranslated region of the message revealed variable numbers of the repeat ranging from 3 to 11 copies. These results will aid in the investigation of a role for this gene in genetic disorders of the dopaminergic system in humans.