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Application of carboxylic-phospholanic mixed anhydrides to fragment coupling in peptide synthesis
C Poulos1, C P Ashton, J Green
1Department of Chemistry, University of Patras, Greece.
International Journal of Peptide and Protein Research
|September 1, 1992
Abstract:
The application of 1-oxo-1-chlorophospholane as a novel reagent for the in situ activation of peptide fragments for use in peptide bond forming reactions, either in liquid or solid phase, has been examined. 24.1 MHz 31P NMR spectroscopy has been employed to follow the formation, stability and reactivity of the intermediate phospholanic-carboxylic mixed anhydride.