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Related Experiment Videos

Audit of bone marrow trephines.

P W Bishop1, K McNally, M Harris

  • 1Department of Histopathology, Christie Hospital, Manchester.

Journal of Clinical Pathology
|December 1, 1992
PubMed
Summary

Many bone marrow trephine biopsy specimens are inadequate due to their length. Establishing clear criteria for specimen adequacy is crucial for accurate cancer diagnosis and treatment planning.

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Area of Science:

  • Hematology
  • Oncology
  • Pathology

Background:

  • Bone marrow trephine biopsy is essential for diagnosing hematological malignancies and staging cancers.
  • Assessing the adequacy of bone marrow specimens is critical for reliable pathological interpretation.

Purpose of the Study:

  • To define criteria for adequate bone marrow trephine biopsy specimens.
  • To evaluate the quality of trephine biopsies performed at a specific hospital.

Main Methods:

  • A retrospective review of 767 bone marrow trephine specimens was conducted.
  • Specimen lengths and constituent parts were measured; operator performance was analyzed.
  • Adequacy criteria were established through literature review and analysis of specimen length versus tumor infiltration.

Main Results:

  • Processed trephines averaged 1.15 cm, with 0.74 cm of interpretable marrow.
  • Established adequacy criteria suggested a minimum length of 1.2 cm in section (1.6 cm before processing).
  • 58% of specimens failed to meet the adequacy criteria, indicating significant quality issues.

Conclusions:

  • Objective criteria reveal a high proportion of inadequate bone marrow trephine biopsies at the studied institution.
  • Operator performance in obtaining adequate specimens varied considerably.
  • The findings highlight the need for improved training and standardization in bone marrow biopsy procedures.

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