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Updated: Aug 19, 2026

Surgical Angiogenesis in Porcine Tibial Allotransplantation: A New Large Animal Bone Vascularized Composite Allotransplantation Model
Published on: August 13, 2017
Bone ingrowth into porous-coated tibial components implanted with autograft bone chips. Analysis of ten consecutively
R D Bloebaum1, M H Rubman, A A Hofmann
1Bone and Joint Research Laboratory, Department of Veterans Affairs Medical Center, Salt Lake City, UT 84148.
Abstract:
Ten asymmetric porous-coated tibial knee components were consecutively retrieved from nine patients with implantation times ranging from 1 week to 48 months. Morselized autograft bone chips were applied to the resected surface of the tibia prior to component implantation. Microradiographic analysis showed bone in contact with 64 +/- 10% of the porous-coated interface. Backscattered electron imaging of the bone-implant interface revealed bone within 8-22% of the porous coating. Although bone in the form of autograft bone chips was observed in the porous coating of the 1 and 3 week specimens, it was not connected to the host bone. By 3 and 6 months, the bone chips were integrated and connected to the host bone providing osseous continuity from the porous coating to the skeleton. This study shows that reproducible bone ingrowth into porous-coated tibial components is achievable using autograft bone chips to promote bone fixation.

