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Updated: Aug 15, 2026

Generation of Monoclonal Antibodies Against Natural Products
Published on: April 6, 2019
Antimutagenic agents from natural products
1Research Triangle Institute, Research Triangle Park, North Carolina 27709.
Abstract:
Certain secondary metabolites found in terrestrial and marine plants and organisms have evinced the capability for inhibiting the mutagenicity toward Salmonella typhimurium of a number of mutagens. These include 2-aminoanthracene (2AN), ethylmethanesulfonate (EMS), and benzo-[a]pyrene(B[alpha]P). The sensitivity of the antimutagenicity assay is such that crude extracts can be evaluated and purification of extracts readily followed. Major classes of antimutagenic compounds that have been isolated include flavonoids, coumarins, and cymopols.
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