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[Bacteriological evaluation of ofloxacin otic solution]
The Japanese Journal of Antibiotics
|October 1, 1992
Summary
Ofloxacin (OFLX) otic solution demonstrated potent antibacterial activity against common ear infection pathogens, including Staphylococcus aureus and Pseudomonas aeruginosa. Clinical trials suggest OFLX otic solution is a clinically useful option for otitis media and external otitis.
Area of Science:
- Microbiology
- Pharmacology
- Otolaryngology
Background:
- Otitis media and external otitis are common ear infections.
- Identifying causative organisms and their antibiotic susceptibilities is crucial for effective treatment.
Purpose of the Study:
- To evaluate the efficacy and antibacterial spectrum of ofloxacin (OFLX) otic solution.
- To compare OFLX's potency against common ear pathogens with other antibacterials.
Main Methods:
- Conducted multiple clinical trials (Phase II, Phase III, open studies) from February 1988 to October 1989.
- Isolated and identified 746 organisms from middle and external ear secretions.
- Determined the minimum inhibitory concentration (MIC90) of OFLX and other antibiotics against isolated strains.
Main Results:
- Aerobic Gram-positive organisms (66.9%) and Gram-negative organisms (32.4%) were the most prevalent pathogens.
- Ofloxacin (OFLX) showed potent activity, with MIC90 of 6.25 µg/ml, being 8-32 times more potent than cefmenoxime, fosfomycin, and fradiomycin.
- OFLX demonstrated superior activity against glucose-nonfermentative Gram-negative rods (GNF-GNR), including Pseudomonas aeruginosa.
Conclusions:
- Ofloxacin (OFLX) otic solution exhibits well-balanced antibacterial activity and a favorable post-antibiotic effect.
- OFLX otic solution possesses advantageous properties compared to other available otic solutions, suggesting clinical utility.