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[der(1;7) (q10;p10) in three patients with malignant hematologic disorders]
1Department of Clinical Laboratories, Saitama Central Hospital.
[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|December 1, 1992
Summary
The derivative chromosome der(1;7) (q10;p10) was found in three patients with hematologic disorders. This chromosomal abnormality is associated with a poor prognosis and resistance to chemotherapy.
Area of Science:
- Hematology
- Cytogenetics
- Oncology
Background:
- The derivative chromosome der(1;7) (q10;p10) involves rearrangements between chromosomes 1 and 7.
- This chromosomal abnormality has been observed in various hematologic malignancies.
Observation:
- Three male patients, aged 39-76, were diagnosed with acute myeloblastic leukemia (AML), myelodysplastic syndrome (MDS), or myeloproliferative disorder (MPD).
- All patients presented with the der(1;7) (q10;p10) chromosomal abnormality in their bone marrow cells.
- One patient had a history of IgG myeloma treated with chemotherapy.
Findings:
- The der(1;7) (q10;p10) abnormality was identified in all three patients.
- All patients exhibited resistance to chemotherapy.
- The patients had a short survival time, succumbing within four months of diagnosis.
Implications:
- The presence of der(1;7) (q10;p10) may signify a poor prognostic outcome in patients with malignant hematologic disorders.
- This finding highlights the importance of cytogenetic analysis in diagnosing and predicting the course of hematologic malignancies.
- Further research is warranted to understand the specific mechanisms by which der(1;7) (q10;p10) contributes to disease progression and treatment resistance.