Related Experiment Video
Updated: Jul 10, 2026
11:29
HPLC-based Assay to Monitor Extracellular Nucleotide/Nucleoside Metabolism in Human Chronic Lymphocytic Leukemia Cells
Published on: July 20, 2016
[Eosinophilic leukemia with cyclic eosinophilic leukocytosis]
E Sada1, K Yanagisawa, H Hasegawa
1First Department of Internal Medicine, Faculty of Medicine, Ehime University.
[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|December 1, 1992
Summary
This study investigates cyclic eosinophilic leukocytosis in a patient diagnosed with eosinophilic leukemia. The condition was found to stem from a hematopoietic stem cell disorder, not serum factors.
Area of Science:
- Hematology
- Oncology
- Stem Cell Biology
Background:
- Eosinophilic leukemia is a rare hematologic malignancy characterized by excessive eosinophil production.
- Cyclic variations in leukocyte and eosinophil counts can complicate diagnosis and treatment of hematologic disorders.
Observation:
- A 36-year-old male presented with anemia, eosinophilia, and hepatosplenomegaly.
- Peripheral blood analysis revealed severe anemia, thrombocytopenia, and marked leukocytosis with atypical eosinophils.
- Elevated serum vitamin B12 and low IgE levels were noted.
Findings:
- The patient exhibited spontaneous fluctuations in eosinophil and total leukocyte counts, indicative of cyclic eosinophilic leukocytosis.
- Analysis revealed no eosinophil colony-stimulating activity in the patient's serum or plasma.
- The cyclic leukocytosis was attributed to a primary hematopoietic stem cell disorder.
Implications:
- This case highlights a novel mechanism for cyclic eosinophilic leukocytosis, distinct from previously described causes.
- Understanding the role of hematopoietic stem cell disorders is crucial for managing rare leukemias.
- Further research into stem cell dysregulation may offer new therapeutic targets for eosinophilic malignancies.
Related Concept Videos
01:27Disorders of Leukocytes
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...
01:30Leishmaniasis
Leishmaniasis is a protozoal disease caused by species of the genus Leishmania and transmitted through the bite of infected female sandflies. The parasite exists in two principal morphological forms during its life cycle. A sandfly acquires intracellular amastigotes from an infected reservoir host, such as a dog. Within the sandfly, these forms differentiate into motile, flagellated promastigotes. During a subsequent blood meal, promastigotes are injected into the human host, where they...
01:28Asthma I: Introduction
Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...