Topical ocular anesthetics in ocular irritancy testing: a review
R A Durham1, D C Sawyer, W F Keller
1Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing 48824-1317.
Laboratory Animal Science
|December 1, 1992
Summary
Topical anesthetics may not effectively reduce discomfort during ocular irritancy tests. More research is needed to find safe and effective pain relief for test animals without impacting results.
Area of Science:
- Veterinary ophthalmology
- Toxicology
- Animal welfare science
Background:
- Topical anesthetics are often used to reduce pain in animal models during ocular irritancy testing.
- Concerns exist regarding their efficacy, safety, and potential to interfere with test outcomes.
Purpose of the Study:
- To review the adverse effects of topical ocular anesthetics.
- To evaluate their practicality and effectiveness in ocular irritancy protocols.
- To determine if long-term use is contraindicated or if side effects cause animal suffering.
Main Methods:
- Literature review of adverse effects of topical ocular anesthetics.
- Analysis of existing data on anesthetic use in ocular irritancy testing protocols.
- Assessment of potential impact on test substance response and animal welfare.
Main Results:
- No evidence supports the use of any specific topical anesthetic for ocular irritancy testing.
- Limited information was found on systemic analgesics or local anesthetic combinations for effective discomfort alleviation.
- Potential for side effects causing pain and suffering in test animals was noted.
Conclusions:
- The efficacy and safety of topical anesthetics in ocular irritancy testing remain unproven.
- Further comprehensive studies are essential to identify optimal drug combinations for ameliorating animal discomfort.
- Such research should prioritize minimizing interference with test results and ensuring animal welfare.
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