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Steroid resistance in asthma: our current understanding
A K Kamada1, D Y Leung, S J Szefler
1Ira J. and Jacqueline Neimark Laboratory for Clinical Pharmacology in Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206.
Pediatric Pulmonology
|November 1, 1992
Summary
Identifying steroid-resistant asthma early is crucial. A 10-day high-dose glucocorticoid trial can help pinpoint patients needing alternative asthma treatments, avoiding unnecessary therapy.
Area of Science:
- Pulmonology
- Pharmacology
Background:
- Steroid-resistant asthma presents a clinical challenge for healthcare providers.
- Understanding the mechanisms of steroid resistance is vital for advancing asthma research.
Purpose of the Study:
- To highlight the importance of early identification of steroid-resistant asthma.
- To suggest an adequate trial duration for systemic glucocorticoid therapy to identify non-responders.
Main Methods:
- Review of current literature on steroid-resistant asthma.
- Discussion of proposed diagnostic criteria for identifying steroid resistance.
Main Results:
- Early identification of steroid-resistant asthma is essential to discontinue ineffective treatments.
- A 10-day course of high-dose systemic glucocorticoids (≥30 mg/day) may serve as an adequate trial.
Conclusions:
- Adherence to early identification principles is recommended until definitive markers for steroid resistance are established.
- Further research into the mechanisms of steroid resistance is needed for a more rational selection of alternative asthma therapies.