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Synthesis, structure and biological activity of 1,2,4-triazolo-1,3-thiazine derivatives
1Department of Organic Chemistry, Medical Academy of Gdańsk, Poland.
Die Pharmazie
|October 1, 1992
Abstract:
A group of condensed triazole-thiazine derivatives (2a-i, 3b, 3j) was obtained in reaction of the corresponding 5-substituted 1,2,4-triazole-3-thiones (1a-j) with epichlorohydrin in alkaline medium. The structure of the compounds synthesized was confirmed by spectral and roentgenographic methods. Tuberculostatic and circulatory activities of the compounds were also studied.