Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dose-time factors in head and neck data.

J M Taylor1, H R Withers

  • 1Department of Radiation Oncology, UCLA Medical Center 90024-1714.

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
|December 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Time factor and treatment strategies in subclinical disease.

International journal of radiation biology·2003
Same author

Endothelial cells and radiation gastrointestinal syndrome.

Science (New York, N.Y.)·2001
Same author

Molecular pathways that modify tumor radiation response.

American journal of clinical oncology·2001
Same author

Basic principles and reasonable speculations in intravascular brachytherapy.

Cardiovascular radiation medicine·2001
Same author

Biological aspects of conformal therapy.

Acta oncologica (Stockholm, Sweden)·2000
Same author

Transmutability of dose and time. Commentary on the first report of RTOG 90003 (K. K. FU et al.)

International journal of radiation oncology, biology, physics·2000
Same journal

Pre-treatment PSQA - Do we still need to measure and what are adequate alternatives?

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2026
Same journal

Dosimetric verification of every treatment plan: Do or not to do?

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2026
Same journal

Pre-treatment PSQA - Do we still need to measure and what are adequate alternatives?

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2026
Same journal

Pre-treatment PSQA - Do we still need to measure and what are adequate alternatives? Optimizing PSQA in radiotherapy workflows through commissioning and standardized treatment planning with class solutions.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2026
Same journal

Pre-treatment PSQA - Do we still need to measure and what are adequate alternatives?

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2026
Same journal

How to focal boost in prostate cancer radiotherapy: ESTRO clinical practice consensus recommendations.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2026
See all related articles

Small sample sizes hinder detecting dose-response relationships in head and neck cancer. However, analysis suggests both radiation dose and time influence tumor control rates.

Area of Science:

  • Radiation Oncology
  • Clinical Trials
  • Biostatistics

Background:

  • Interpreting dose-time effects on tumor control is crucial in head and neck cancer treatment.
  • Many clinical studies have limited sample sizes, potentially obscuring statistically significant findings.
  • Previous analyses suggest a relationship between radiation dose, treatment time, and tumor control.

Purpose of the Study:

  • To evaluate the statistical power of detecting dose-response relationships in head and neck cancer clinical series.
  • To investigate the influence of both radiation dose and overall treatment time on tumor control rates.
  • To compare findings with previous analyses of institutional data.

Main Methods:

  • Statistical analysis of tumor control rate data from multiple institutions.

Related Experiment Videos

  • Application of a non-parametric regression technique to assess dose-time effects.
  • Evaluation of sample size limitations in detecting dose-response relationships.

    • Main Results:

    • Many clinical series possess insufficient sample sizes to statistically confirm dose-response relationships.
    • Non-parametric regression analysis indicates that both radiation dose and time significantly influence tumor control rates.
    • The observed influence of dose and time qualitatively aligns with previous research findings.

    Conclusions:

    • Detecting subtle dose-response effects in head and neck cancer requires adequately powered studies.
    • Both radiation dose and overall treatment time are critical factors affecting tumor control outcomes.
    • Further research with larger datasets is warranted to refine understanding of dose-time effects.