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An analysis of two-period crossover designs with carry-over effects
N M Laird1, J Skinner, M Kenward
1Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115.
Statistics in Medicine
|October 1, 1992
Abstract:
The crossover design is a type of longitudinal study with subjects receiving different treatments in different time periods. When carry-over effects are absent, the usual crossover design is structured so that all the information about treatment effects is contained in the within-subject contrasts; standard analyses are based on these within-subject contrasts and ignore any between-subject information. With carry-over effects present these standard analyses can be very inefficient, especially for suboptimal designs. We describe alternative approaches based on methods for the analysis of longitudinal data.