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Application of the Starling resistor concept to the lungs during CPPV.
Critical Care Medicine
|March 1, 1977
Summary
Continuous positive pressure ventilation (CPPV) increases lung resistance, impacting hemodynamics. This study shows the pulmonary vasculature acts as a Starling resistor during CPPV, necessitating careful consideration of increased pulmonary vascular resistance.
Area of Science:
- Physiology
- Respiratory Medicine
- Cardiovascular Physiology
Background:
- Continuous positive pressure ventilation (CPPV) is a mechanical ventilation method.
- The Starling resistor concept describes fluid flow through collapsible vessels.
Purpose of the Study:
- To evaluate the Starling resistor concept in the lungs during CPPV.
- To assess the impact of CPPV on respiratory and hemodynamic parameters.
Main Methods:
- Eight anesthetized and paralyzed dogs were studied.
- Ventilation and hemodynamic parameters were measured before and during CPPV.
Main Results:
- CPPV increased transpulmonary pressure and functional residual capacity (FRC).
- Arterial pH and mixed venous oxygen tension (PvO2) decreased.
- Cardiac index and stroke volume significantly decreased.
- Pulmonary vascular resistance increased by 189%.
Conclusions:
- The pulmonary vasculature behaves as a Starling resistor under CPPV.
- Increased pulmonary vascular resistance during CPPV must be considered.
- CPPV affects respiratory mechanics and cardiovascular function.