Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

[Determining progesterone in saliva].

H Herges¹, W Klinger, U Gethmann

¹Frauenklinik, Städtischen Kliniken Osnabrück.

Zentralblatt Fur Gynakologie

|January 1, 1992

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Safety and psychological impact of sailing adventure therapy among Veterans with substance use disorders.

Complementary therapies in medicine·2018

Same author

Estrogen responsiveness of progestin receptor induction in the pituitary, preoptic-hypothalamic brain and uterus of neonatally estrogenized female rats.

Brain research·2013

Same author

Production of the Neurosteroid 3alpha-Hydroxy-5alpha-pregnan-20-one in Man.

Journal of neuroendocrinology·2009

Same author

Recent advances in the diagnosis of malignant hyperthermia susceptibility: how confident can we be of genetic testing?

European journal of human genetics : EJHG·2003

Same author

Estradiol, testosterone, dehydroepiandrosterone and androstenedione: novel derivatives and enantiomers. Interactions with rat liver microsomal cytochrome P450 and antioxidant/radical scavenger activities in vitro.

Toxicology letters·2002

Same author

Interactions of melatonin with the liver microsomal cytochrome P450 system of rats and humans in vitro and effects on the P450 system and the antioxidative status in rat liver after acute treatment.

European journal of drug metabolism and pharmacokinetics·2001

A new radioimmunoassay accurately measures salivary progesterone. However, this method did not clearly show typical progesterone rhythms during the menstrual cycle, suggesting serum measurements may be better for diagnosing infertility.

Area of Science:

Endocrinology
Biochemistry

Context:

Salivary hormone analysis offers a non-invasive method for monitoring endocrine function.
Accurate measurement of hormones like progesterone is crucial for understanding reproductive health and diagnosing conditions.

Purpose:

To develop and validate a sensitive radioimmunoassay (RIA) for determining progesterone levels in human saliva.
To investigate the presence and characteristics of progesterone rhythms in saliva during the normal menstrual cycle and assess circadian variations.

Summary:

A highly sensitive radioimmunoassay (3.12 pg/ml) was developed for salivary progesterone using a 125I-labelled derivative.
The study found that biphasic progesterone rhythms were not clearly demonstrated in saliva during the menstrual cycle, with irregular oscillations observed.

Related Experiment Videos

Saliva flow rate did not correlate with progesterone concentration, and serum progesterone measurement appeared more clinically relevant for diagnosing sterility.

Impact:

Highlights the limitations of salivary progesterone measurements for accurately reflecting cyclical hormonal changes.
Suggests that serum progesterone analysis remains a more reliable tool for clinical diagnostics, particularly in evaluating infertility.
Provides a sensitive assay for salivary progesterone, which may still hold value for specific research applications or non-cyclical hormonal assessments.