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Related Experiment Videos

Hypothermia, Wernicke encephalopathy and multiple sclerosis.

C Geny1, P F Pradat, J Yulis

  • 1Department of Neurosciences, Henri Mondor Hospital, Créteil, France.

Acta Neurologica Scandinavica
|December 1, 1992
PubMed
Summary

Neurological exacerbations in multiple sclerosis (MS) patients may signal Wernicke encephalopathy (WE), a reversible condition. Prompt thiamine treatment rapidly improved symptoms, including hypothermia, in two MS patients.

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Area of Science:

  • Neurology
  • Neuroscience
  • Internal Medicine

Background:

  • Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system, typically causing neurological exacerbations due to demyelination.
  • Hypothermia is an uncommon symptom in MS patients, often attributed to hypothalamic demyelination.
  • Wernicke encephalopathy (WE) is a serious neurological disorder typically associated with thiamine deficiency.

Observation:

  • Two patients with MS presented with neurological exacerbation and hypothermia (32.4°C and 32.5°C).
  • Clinical presentation and rapid response to intravenous thiamine strongly suggested WE as the cause.
  • Hypothermia, usually linked to demyelination in MS, was observed in these cases.

Findings:

  • Wernicke encephalopathy (WE) can manifest with hypothermia and neurological exacerbation in patients with multiple sclerosis (MS).

Related Experiment Videos

  • Parenteral thiamine administration led to rapid clinical improvement, confirming WE as the likely diagnosis.
  • This association highlights WE as a potential cause of reversible hypothermia in the MS population.

    • Implications:

    • Highlights the importance of considering Wernicke encephalopathy in MS patients presenting with neurological decline and hypothermia.
    • Suggests that prompt thiamine supplementation can reverse neurological symptoms and hypothermia in this specific patient group.
    • Broadens the differential diagnosis for neurological exacerbations in MS, including non-demyelinating causes like WE.